Investigation of TLR4, TLR6, TLR7, and CD36 expression on T lymphocytes in coronary artery disease
This study aimed to investigate the levels of TLR4, TLR6, and TLR7, as well as CD36 cell surface markers in CAD.
Saeedeh Asgarbeik, Elina Smailey, Elika Esmaeilzadeh Gharehdaghi, Somayeh Parichehreh-Dizaji, Seyed Kianoosh Hosseini, Farzaneh Esmaily, Mahsa M Amoli. Investigation of TLR4, TLR6, TLR7, and CD36 expression on T lymphocytes in coronary artery disease. GenoMed Connect. 10 Sep 2024. https://doi.org/10.69709/GenomC.2024.197851
Abstract
Background: Coronary artery disease (CAD) is among the significant causes of death globally, caused by fatty deposits in blood vessel walls. Increasing evidence indicates that toll-like receptors (TLRs) are pivotal to atherosclerosis progression. The function of CD36 as a glycoprotein in atherosclerosis was also suggested. This study aimed to investigate the levels of TLR4, TLR6, and TLR7, as well as CD36 cell surface markers in CAD. Methods: This study included 64 patients undergoing angiography to determine whether atherosclerosis was present. The patients were categorized into two groups. The three main coronary arteries are all stenosed at over 50% in patients with CAD+ (n=22) as cases and CAD− (n=42) with smooth angiography as controls. Each patient's syntax score (SS) and Gensini (vessel score) were calculated. The TLR-4, TLR-6, TLR-7, and CD36 expression were measured using Flow cytometry. Results: TLR4 and TLR6 showed a significant link with the Gensini score in the subject group. In addition, TLR7 had an association with Syntax scoring in this study. Conclusion: Our findings illustrated the association between TLR4, TLR6, and TLR7 cell surface markers with Gensini and Syntax scoring in individuals with coronary artery disease.
Keywords: Coronary artery disease; TLR4; TLR6; TLR7; CD36
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