The Next-generation sequencing of obesity genes using the bioinformatics approach for genotype and haplotype study

The prevalence of obesity has increased significantly in recent decades. Monogenic obesity is a rare type of severe obesity that develops during childhood. In this type of obesity, the appetite and food intake of the individual are affected abnormally by a mutation in a single gene. Since this disease has not been studied in detail, and given the high percentage of consanguineous marriages in Iran and the higher probability of childhood obesity in the Iranian population, the present study investigates the discovery of new genetic effects in this type of obesity. The results and experiences of this project can be used to help identify the factors that cause this obesity and to design treatment guidelines and management of severe obesity in Iranian children. This study was designed to help identify the genetic factors affecting monogenic obesity in the Iranian population. Identifying the genetic changes that affect weight gain and appetite control in these patients is essential for treatment. In addition, such studies can provide the necessary insight for conducting future experimental and functional studies and a better understanding of the mechanisms involved in this disease.