The study of new genotypes and haplotypes related to monogenic diabetes using whole exome sequencing (WES) and bioinformatics approach
The prevalence of diabetes, as one of the most important endocrine diseases, has increased significantly in recent decades. Monogenic diabetes is a type of diabetes that is directly caused by a change in a gene that occurs at an early age in a person's life. Since this disease has not been studied in detail in Iran, and given the high percentage of consanguineous marriages in Iran and the higher probability of monogenic diabetes in the Iranian population, the present study investigates the discovery of new genetic effects in this type of diabetes in individuals aged 6 months to 18 years. The results and experiences of this project can be used to help identify the factors that cause this type of diabetes and to design treatment guidelines and management of monogenic diabetes in Iran. This study was designed to help identify the genetic factors affecting monogenic diabetes in the Iranian population. Identifying genetic changes that affect the risk of developing this disease is essential for treatment. In addition, such studies can provide the necessary insight for conducting future experimental and functional studies and a better understanding of the mechanisms involved in this disease.
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